Integrated Microfluidic Card with TaqMan Probes and High-Resolution Melt Analysis To Detect Tuberculosis Drug Resistance Mutations across 10 Genes

ABSTRACT Genotypic methods for drug susceptibility testing of Mycobacterium tuberculosis are desirable to speed the diagnosis and proper therapy of tuberculosis (TB).However, the numbers of genes and polymorphisms implicated in resistance have proliferated, challenging diagnostic design.We developed a microfluidic TaqMan array card (TAC) that utili

read more

Complete and Partial Lesions of the Pyramidal Tract in the Rat Affect Qualitative Measures of Skilled Movements: Impairment in Fixations as a Model for Clumsy Behavior

Little is known about prenatal and perinatal brain injury resulting in subsequent clumsy behavior in children.One candidate motor system is the pyramidal tract.The tract traverses the entire central nervous system and, through direct and indirect connections to the brainstem and spinal cord sensory Dental Treats and motor nuclei, is involved in the

read more

Echoes in correlated neural systems

Correlations are employed in modern physics to explain microscopic and Carnosine macroscopic phenomena, like the fractional quantum Hall effect and the Mott insulator state in high temperature superconductors and ultracold atoms.Simultaneously probed neurons in the intact brain reveal correlations between their activity, an important measure to stu

read more


Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory

Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and Dehydrated Treats function within changing cellular environments.Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental cues that infl

read more